Endothelin-1-induced vasoconstriction causes a significant increase in portal pressure of rat liver: localized constrictive effect on the distal segment of preterminal portal venules as revealed by light and electron microscopy and serial reconstruction

In smooth muscle cells, activation of ET A and ET B receptors leads to vascular vasoconstriction. The activation of ET B receptors in endothelial cells leads to NO

Administration of endothelin-1 to animals in vivo increases renin, aldosterone, and epinephrine concentrations; here, renin concentration seems to rise because of endothelin-1 induced renal vasoconstriction (Kennedy et al., 1993). Endothelin B receptor-mediated vasoconstriction induced by endothelin A receptor antagonist Yi Zhang, Yi Zhang a a Cardiology Unit, The Queen Elizabeth Hospital, We investigated the effect of endothelin-1 (ET) on cytosolic free Ca2+ concentration ( [Ca2+]i) and intracellular Ca2+store in vascular smooth muscle cells (VSMCs). Teerlink J R, Breu V, Sprecher U et al.,Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries, Circ. Res. (1994);74: pp. 105-114. First, endothelin-dependent vasoconstriction is maximal at 34 μU/ml of insulin , but blocking endothelin receptors does not reveal insulin-induced dilatation at that concentration . Second, maximal NO-dependent vasodilatation occurs at a concentration of insulin of 3.4 mU/ml ( Fig. 2 ), but NOS inhibition does not reveal insulin-induced vasoconstriction at that concentration ( Fig. 3 ).

Endothelin vasoconstriction

The endothelium is crucially involved in the maintenance of vascular homeostasis. 4 Normal endothelial function mainly depends on the capacity of endothelial cells to produce NO, which is vasoprotective by inhibiting cytokine expression, smooth muscle cell migration, leukocyte adhesion, and platelet aggregation, as well as improving vasodilatory function. 5 TZDs improve endothelial dysfunction. Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure Lancet 1995; 358: 732-6. Kohan DE Endothelin-1 and hypertension: from bench to bedside. Curr Hypertens Rep 2008; 10:65-9.

Endothelins (EDNs) are a peptide family consisting of three different members (EDN1, EDN2, and EDN3) and sarafotoxins, which were originally defined by their vasoconstrictive actions.458 From: Knobil and Neill's Physiology of Reproduction (Fourth Edition), 2015

The effects mediated by ET-1 via ETRA are vasoconstriction, bronchoconstriction and secretion of aldosterone. Figure 1|Kinetics of renal arteriolar vasoconstriction in response to angiotensin II (Ang II) and endothelin-1 (ET-1) in Sprague–Dawley (SD) rats.

John Pernow och Jan M. Lundberg: Myocardial release, tissue content and coronary vasoconstrictor effects of endothelin in relation to ischemia and reperfusion

Edvinsson, L, Povlsen, GK, Ahnstedt, H & Waldsee, R 2014, ' CaMKII inhibition with KN93 attenuates endothelin and serotonin receptor-mediated vasoconstriction and prevents subarachnoid hemorrhage-induced deficits in sensorimotor function. Vasoconstrictors like angiotensin II, vasopressin and endothelin are powerful vasoconstrictorsSubscribe to our channel for daily notes for Medical students. Endothelin-1 (ET-1) is a 21 amino acid peptide that is produced by the vascular endothelium (click here for details). It is a very potent vasoconstrictor that binds One such vasoconstrictor was described initially by Hickey et al.1. Subsequently, in the supernatant of cultured porcine aortic endothelial cells, Yanagisawa et al2 Aug 30, 2011 Both ETA and ETB receptors are expressed by renal microvascular smooth muscle cells, where activation causes vasoconstriction. In 1985, Hickey showed that the vascular endothelium generates a vasoconstrictor substance that produces pro- longed vasoconstriction [2].

/ Eskesen, K; Edvinsson, Lars.. I: European Journal of Pharmacology, Vol. 539, Nr. 3, 2006, s.
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Upregulation of endothelin ETB receptor-mediated vasoconstriction in rat coronary artery after organ culture. / Eskesen, K; Edvinsson, Lars.. I: European Journal of Pharmacology, Vol. 539, Nr. 3, 2006, s. 192-194.

It is a very potent vasoconstrictor that binds One such vasoconstrictor was described initially by Hickey et al.1. Subsequently, in the supernatant of cultured porcine aortic endothelial cells, Yanagisawa et al2 Apr 21, 2004 Remodeling of resistance arteries is a key feature in hypertension.
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John Pernow och Jan M. Lundberg: Myocardial release, tissue content and coronary vasoconstrictor effects of endothelin in relation to ischemia and reperfusion

The three peptides produce vasoconstrictor and pressor Vascular hindrance, a calculation of blood pressure divided by blood flow and viscosity, was raised by about 20%, suggesting marked vasoconstriction of Endothelin-1 is a potent vasoconstrictor mediating its effects via two receptor preferentially situated on smooth muscle cells, mediating vasoconstriction and… av JC McGrath · 2009 · Citerat av 1 — RC et al. (2009). Increased endothelin-1 reactivity and endothelial vasoconstriction and increases in endothelial cell Ca2+ in hamster cremaster arterioles. normal vasodilation and vasoconstriction blood vessel vector Structure of human endothelin-1, a polypeptide hormone regulator of blood pressure, 3D.